|
|
7alpha-hydroxycholesterol + NAD+ <=> 7alpha-hydroxy-4-cholesten-3-one + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.181
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
|
–
–
|
BMK
|
| |
BRENDA:
BR29239
KEGG:
R04263
MetaCyc:
1.1.1.181-RXN
SABIO-RK:
9288
|
|
|
|
cholesterol + reduced_flavodoxin + O2 <=> 7alpha-hydroxycholesterol + flavin + H2O
|
1.14.14.23
cholesterol 7alpha-monooxygenase
|
–
|
BK
|
| |
BRENDA:
BR29138
KEGG:
R01463
|
|
|
|
7alpha-hydroxycholesterol + NADP+ <=> 7-oxocholesterol + NADPH
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS372213
SABIO-RK:
7918
|
|
|
|
7alpha-hydroxycholesterol + NADP+ <=> 7alpha-hydroxy-4-cholesten-3-one + NADPH + H+
|
1.1.1.181
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
|
–
|
|
| |
KEGG:
R04264
|
|
|
|
cholesterol + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 7alpha-hydroxycholesterol + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.23
cholesterol 7alpha-monooxygenase
|
–
|
M
|
| |
MetaCyc:
CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
|
|
|
|
7alpha-hydroxycholesterol + O2 <=> 7alpha-hydroxy-4-cholesten-3-one + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
|
| |
BRENDA:
BS404106
|
|
|
|
oleoyl-CoA + 7alpha-hydroxycholesterol <=> CoA + 7alpha-hydroxycholesteryl_oleate
|
2.3.1.26
sterol O-acyltransferase
|
–
|
|
| |
BRENDA:
BS380170
|
|
|
|
a_[lipoyl-carrier_protein]-N6-[(R)-dihydrolipoyl]-L-lysine + cholesterol_7alpha-hydroperoxide <=> a_[lipoyl-carrier_protein]-N6-lipoyl-L-lysine + H2O + 7alpha-hydroxycholesterol
|
1.11.1.28
lipoyl-dependent peroxiredoxin
|
–
|
|
| |
BRENDA:
BS449406
|
|
|
|
cholesterol_7alpha-hydroperoxide + glutathione <=> 7alpha-hydroxycholesterol + GSSG
|
1.11.1.9
glutathione peroxidase
|
–
|
|
| |
BRENDA:
BS261211
|
|
|
|
2 7-oxocholesterol + 2 NADPH + 2 H+ <=> 7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADPH
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.B40
|
–
–
|
|
| |
BRENDA:
BS372211
|
|
|
|
Metyrapone + NADPH + H+ <=> 7alpha-hydroxycholesterol + NADP+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS439753
|
|
|
|
metapyrone + NADPH + H+ <=> 7alpha-hydroxycholesterol + NADP+
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS450934
|
|
|
|
3''-phosphoadenylyl_sulfate + 7alpha-hydroxycholesterol <=> adenosine_3'',5''-bisphosphate + 7alpha-hydroxycholesteryl_sulfate
|
2.8.2.15
steroid sulfotransferase
|
–
|
|
| |
BRENDA:
BS387260
|
|
|
|
3''-phosphoadenylyl_sulfate + 7alpha-hydroxycholesterol <=> adenosine_3'',5''-bisphosphate + 7alpha-hydroxycholesterol_3-sulfate
|
2.8.2.2
alcohol sulfotransferase
|
–
|
|
| |
BRENDA:
BS399570
|
|
|
|
7alpha-hydroxycholesterol + reduced_adrenodoxin + O2 <=> 5-cholestene-3alpha,7alpha,26-triol + oxidized_ferredoxin + H2O
|
1.14.15.15
cholestanetriol 26-monooxygenase
|
–
|
|
| |
BRENDA:
BS386155
|
|
|
|
O2 + NADPH + H+ + cholesterol <=> H2O + 7alpha-hydroxycholesterol + NADP+
|
1.14.14.23
cholesterol 7alpha-monooxygenase
|
–
|
|
| |
SABIO-RK:
1640
|
|
